Electromechanical modeling of human ventricles with ischemic cardiomyopathy: numerical simulations in sinus rhythm and under arrhythmia

We developed a novel patient-specific computational model for the numerical simulation of ventricular electromechanics in patients with ischemic cardiomyopathy (ICM). This reproduces activity both sinus rhythm (SR) and tachycardia (VT). The presence scars, grey zones non-remodeled regions myocardium is accounted by introduction spatially heterogeneous coefficient 3D model. firstly coupled 2-element Windkessel afterload to fit pressure-volume (PV) loop left ventricle (LV) ICM SR. Then, we employ coupling 0D closed-loop circulation analyze VT circuit over multiple heartbeats on same LV. highlight similarities differences solutions obtained electrophysiology those model, while considering different scenarios circulatory system. observe that very parametrizations induce hemodynamical considerations patient at hand. Specifically, classify this as unstable. conclude stressing importance combining electrophysiological, mechanical models provide relevant clinical indicators how arrhythmias evolve can potentially lead sudden cardiac death.